Effects of O-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis
نویسندگان
چکیده
State Key Laboratory of Genetic Engineering and the MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, People’s Republic of China, Department of Health Toxicology, Shanghai Second Military Medical University, Shanghai 200433, People’s Republic of China and Life Science Institute, Nanchang University, Jiangxi Province 330031, People’s Republic of China
منابع مشابه
بررسی نقش پلی مورفیسمهای ژن O6 – متیل گوانین متیل ترانسفراز در سرطان کولورکتال
Abstract Background: Sporadic colorectal cancer is the fourth most common cancer in Iran. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is involved in the cellular defense against alkylating agents. Genetic alterations in the MGMT gene may impair the protein’s ability to remove alkyl groups from the O6-position of guanine, thereby raising the mutation rate and increasi...
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Background: ATP-binding cassette membrane transporter G2 (ABCG2) gene is one of transporter family and well characterized for their association with chemoresistance. Promoter methylation is a mechanism for regulation of gene expression. O6-Methyl guanine DNA methyl transferase (MGMT) gene plays a fundamental role in DNA repair. MGMT has the ability to remove alkyl adducts from DNA at the O6 pos...
متن کاملThe role of O(6)-methylguanine-DNA methyltransferase polymorphisms in colorectal cancer susceptibility: a meta analysis.
OBJECTIVE O(6)-methylguanine DNA methyl-transferase gene (MGMT) is a central DNA repair mechanism with a significant role in removing DNA damage caused by alkylating agents and inhibiting human oncogenesis. Two single polymorphisms in the MGMT gene, Leu84Phe and Ile143Val, have been reported to affect DNA repair capability and enzymic activity, thereby leading to formation of different cancers....
متن کاملEffects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer.
BACKGROUND AND AIM The present study was designed to consider whether amino acid substitution polymorphisms in O6-methylguanine-DNA methyltransferase (MGMT) and DNA methyl transferase 1 (DNMT1) genes may be associated with the genetic susceptibility to sporadic colorectal cancer. PATIENTS AND METHODS We assessed eight non-synonymous polymorphisms of these two genes by PCR/pyrosequencing. Our ...
متن کاملRibozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression.
A synthetic oligonucleotide containing ribozyme sequences targeted to the 5' region of the human O6-methylguanine-DNA methyltransferase (MGMT) mRNA has been constructed. This ribozyme demonstrates cleavage activity in vitro in the presence of Mg2+. To determine whether this ribozyme can function in vivo, HeLa CCL2 cells were transfected with a mammalian expression vector containing the ribozyme...
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